mTOR drives its own activation via SCF(β-TRCP)-dependent degradation of the mTOR inhibitor DEPTOR

The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of the mTOR network. DEPTOR stability is governed by the 26S-proteasome through a largely unknown mechanism. Here...

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Detalhes bibliográficos
Main Authors: Gao, Daming, Inuzuka, Hiroyuki, Tan, Meng-Kwang Marcus, Fukushima, Hidefumi, Locasale, Jason W., Liu, Pengda, Wan, Lixin, Zhai, Bo, Chin, Y. Rebecca, Shaik, Shavali, Lyssiotis, Costas A., Gygi, Steven P., Toker, Alex, Cantley, Lewis C., Asara, John M., Harper, J. Wade, Wei, Wenyi
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229299/
https://ncbi.nlm.nih.gov/pubmed/22017875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.030
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