mTOR drives its own activation via SCF(β-TRCP)-dependent degradation of the mTOR inhibitor DEPTOR

The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of the mTOR network. DEPTOR stability is governed by the 26S-proteasome through a largely unknown mechanism. Here...

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Main Authors: Gao, Daming, Inuzuka, Hiroyuki, Tan, Meng-Kwang Marcus, Fukushima, Hidefumi, Locasale, Jason W., Liu, Pengda, Wan, Lixin, Zhai, Bo, Chin, Y. Rebecca, Shaik, Shavali, Lyssiotis, Costas A., Gygi, Steven P., Toker, Alex, Cantley, Lewis C., Asara, John M., Harper, J. Wade, Wei, Wenyi
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229299/
https://ncbi.nlm.nih.gov/pubmed/22017875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2011.08.030
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