SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2

The incidence of human papillary thyroid cancer (PTC) is increasing and an aggressive subtype of this disease is resistant to treatment with vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor. VEGFR2 promotes angiogenesis by triggering endothelial cell proliferation and migration. Howe...

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Main Authors: Shaik, Shavali, Nucera, Carmelo, Inuzuka, Hiroyuki, Gao, Daming, Garnaas, Maija, Frechette, Gregory, Harris, Lauren, Wan, Lixin, Fukushima, Hidefumi, Husain, Amjad, Nose, Vania, Fadda, Guido, Sadow, Peter M., Goessling, Wolfram, North, Trista, Lawler, Jack, Wei, Wenyi
פורמט: Artigo
שפה:Inglês
יצא לאור: The Rockefeller University Press 2012
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Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405505/
https://ncbi.nlm.nih.gov/pubmed/22711876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112446
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