SCF(β-TRCP) regulates osteoclastogenesis via promoting CYLD ubiquitination

CYLD negatively regulates the NF-κB signaling pathway and osteoclast differentiation largely through antagonizing TNF receptor-associated factor (TRAF)-mediated K63-linkage polyubiquitination in osteoclast precursor cells. CYLD activity is controlled by IκB kinase (IKK), but the molecular mechanism(...

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Autors principals: Wu, Xiaomian, Fukushima, Hidefumi, North, Brian J., Nagaoka, Yoshiyuki, Nagashima, Katsuyuki, Deng, Feng, Okabe, Koji, Inuzuka, Hiroyuki, Wei, Wenyi
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4147317/
https://ncbi.nlm.nih.gov/pubmed/24961988
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