Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States

Human DNA ligase III has essential functions in nuclear and mitochondrial DNA replication and repair and contains a PARP-like zinc finger (ZnF) that increases DNA nick-joining and intermolecular DNA ligation. Yet, the bases for ligase III specificity and structural variation among human ligases are...

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Hlavní autoři: Cotner-Gohara, Elizabeth, Kim, In-Kwon, Hammel, Michal, Tainer, John A., Tomkinson, Alan E., Ellenberger, Tom
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922849/
https://ncbi.nlm.nih.gov/pubmed/20518483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100503w
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