Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining

Mammalian DNA ligase III (LigIII) functions in both nuclear and mitochondrial DNA metabolism. In the nucleus, LigIII has functional redundancy with DNA ligase I whereas LigIII is the only mitochondrial DNA ligase and is essential for the survival of cells dependent upon oxidative respiration. The un...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kukshal, Vandna, Kim, In-Kwon, Hura, Gregory L., Tomkinson, Alan E., Tainer, John A., Ellenberger, Tom
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538836/
https://ncbi.nlm.nih.gov/pubmed/26130724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv652
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