Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining

Mammalian DNA ligase III (LigIII) functions in both nuclear and mitochondrial DNA metabolism. In the nucleus, LigIII has functional redundancy with DNA ligase I whereas LigIII is the only mitochondrial DNA ligase and is essential for the survival of cells dependent upon oxidative respiration. The un...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Kukshal, Vandna, Kim, In-Kwon, Hura, Gregory L., Tomkinson, Alan E., Tainer, John A., Ellenberger, Tom
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Nucleic Acid Enzymes
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538836/
https://ncbi.nlm.nih.gov/pubmed/26130724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv652
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