Direct interaction of DNA repair protein tyrosyl DNA phosphodiesterase 1 and the DNA ligase III catalytic domain is regulated by phosphorylation of its flexible N-terminus

Tyrosyl DNA phosphodiesterase 1 (TDP1) and DNA Ligase IIIα (LigIIIα) are key enzymes in single-strand break (SSB) repair. TDP1 removes 3′-tyrosine residues remaining after degradation of DNA topoisomerase (TOP) 1 cleavage complexes trapped by either DNA lesions or TOP1 inhibitors. It is not known ho...

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Udgivet i:J Biol Chem
Main Authors: Rashid, Ishtiaque, Hammel, Michal, Sverzhinsky, Aleksandr, Tsai, Miaw-Sheue, Pascal, John M., Tainer, John A., Tomkinson, Alan E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
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Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8318918/
https://ncbi.nlm.nih.gov/pubmed/34181949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100921
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