Identification of Natural Products That Inhibit the Catalytic Function of Human Tyrosyl-DNA Phosphodiesterase (TDP1)

Tyrosyl-DNA phosphodiesterase 1 (TDP1) is an enzyme crucial for cleavage of the covalent topoisomerase 1-DNA complex, an intermediate in DNA repair. TDP1 plays a role in reversing inhibition of topoisomerase I by camptothecins, a series of potent and effective inhibitors used in the treatment of col...

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Detaylı Bibliyografya
Yayımlandı:SLAS Discov
Asıl Yazarlar: Bermingham, Alun, Price, Edmund, Marchand, Christophe, Chergui, Adel, Naumova, Alena, Whitson, Emily L., Krumpe, Lauren R. H., Goncharova, Ekaterina I., Evans, Jason R., McKee, Tawnya C., Henrich, Curtis J., Pommier, Yves, O’Keefe, Barry R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900901/
https://ncbi.nlm.nih.gov/pubmed/28697309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217717200
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