Synthesis and Biological Evaluation of the First Dual Tyrosyl-DNA Phosphodiesterase I (Tdp1) - Topoisomerase I (Top1) Inhibitors

Substances with dual tyrosyl-DNA phosphodiesterase I - topoisomerase I inhibitory activity in one low molecular weight compound would constitute a unique class of anticancer agents that could potentially have significant advantages over drugs that work against the individual enzymes. The present stu...

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Main Authors: Nguyen, Trung Xuan, Morrell, Andrew, Conda-Sheridan, Martin, Marchand, Christophe, Agama, Keli, Bermingam, Alun, Stephen, Andrew G., Chergui, Adel, Naumova, Alena, Fisher, Robert, O’Keefe, Barry R., Pommier, Yves, Cushman, Mark
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350798/
https://ncbi.nlm.nih.gov/pubmed/22536944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300335n
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