5‑Arylidenethioxothiazolidinones as Inhibitors of Tyrosyl–DNA Phosphodiesterase I

Tyrosyl–DNA phosphodiesterase I (Tdp1) is a cellular enzyme that repairs the irreversible topoisomerase I (Top1)–DNA complexes and confers chemotherapeutic resistance to Top1 inhibitors. Inhibiting Tdp1 provides an attractive approach to potentiating clinically used Top1 inhibitors. However, despite...

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Pubblicato in:J Med Chem
Autori principali: Sirivolu, Venkata Ramana, Vernekar, Sanjeev Kumar V., Marchand, Christophe, Naumova, Alena, Chergui, Adel, Renaud, Amelie, Stephen, Andrew G., Chen, Feng, Sham, Yuk Y., Pommier, Yves, Wang, Zhengqiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479925/
https://ncbi.nlm.nih.gov/pubmed/23006064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008773
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