5‑Arylidenethioxothiazolidinones as Inhibitors of Tyrosyl–DNA Phosphodiesterase I

Tyrosyl–DNA phosphodiesterase I (Tdp1) is a cellular enzyme that repairs the irreversible topoisomerase I (Top1)–DNA complexes and confers chemotherapeutic resistance to Top1 inhibitors. Inhibiting Tdp1 provides an attractive approach to potentiating clinically used Top1 inhibitors. However, despite...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Sirivolu, Venkata Ramana, Vernekar, Sanjeev Kumar V., Marchand, Christophe, Naumova, Alena, Chergui, Adel, Renaud, Amelie, Stephen, Andrew G., Chen, Feng, Sham, Yuk Y., Pommier, Yves, Wang, Zhengqiang
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479925/
https://ncbi.nlm.nih.gov/pubmed/23006064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm3008773
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados