Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

Aberrant intracellular Ca(2+) regulation is believed to contribute to the development of cardiomyopathy in Duchenne muscular dystrophy. Here, we tested whether inhibition of protein kinase A (PKA) phosphorylation of ryanodine receptor type 2 (RyR2) prevents dystrophic cardiomyopathy by reducing SR C...

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Detaylı Bibliyografya
Asıl Yazarlar: Sarma, Satyam, Li, Na, van Oort, Ralph J., Reynolds, Corey, Skapura, Darlene G., Wehrens, Xander H. T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2010
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919918/
https://ncbi.nlm.nih.gov/pubmed/20615971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1004509107
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