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Accelerated Development of Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in a RyR2-R176Q Knockin Mouse Model

In response to chronic hypertension, the heart compensates by hypertrophic growth, which frequently progresses to heart failure. Although Ca(2+) has a central role in hypertrophic signaling pathways, the Ca(2+) source for activating these pathways remains elusive. We hypothesized that pathological s...

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Bibliografski detalji
Glavni autori: van Oort, Ralph J., Respress, Jonathan L., Li, Na, Reynolds, Corey, De Almeida, Angela C., Skapura, Darlene G., De Windt, Leon J., Wehrens, Xander H.T.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2843393/
https://ncbi.nlm.nih.gov/pubmed/20157052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.109.146449
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