Long-Term Simulated Microgravity Causes Cardiac RyR2 Phosphorylation and Arrhythmias in Mice

BACKGROUND: Long-term exposure to microgravity during space flight may lead to cardiac remodeling and rhythm disturbances. In mice, hindlimb unloading (HU) mimics the effects of microgravity and stimulates physiological adaptations, including cardiovascular deconditioning. Recent studies have demons...

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Main Authors: Respress, Jonathan L., Gershovich, Pavel M., Wang, Tiannan, Reynolds, Julia O., Skapura, Darlene G., Sutton, Jeffrey P., Miyake, Christina Y., Wehrens, Xander H.T.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195800/
https://ncbi.nlm.nih.gov/pubmed/25227892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2014.08.138
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