Downregulation of Cystine Transporter x(c)(–) by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

BACKGROUND: The purpose of this study was: (1) to document the critical requirement of cystine for growth of human tumor cells in vitro, and (2) to determine the effect of the anticancer agent irinotecan on the cystine transporter x(c)(–) in head and neck FaDu xenografts. METHODS: Cell growth was me...

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Detalhes bibliográficos
Main Authors: Chintala, Sreenivasulu, Tóth, Károly, Yin, Ming-Biao, Bhattacharya, Arup, Smith, Sylvia B., Ola, M. Shamsul, Cao, Shousong, Durrani, Farukh A., Zinia, Tanjima R., Dean, Rebecca, Slocum, Harry K., Rustum, Youcef M.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
Assuntos:
Experimental Chemotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914432/
https://ncbi.nlm.nih.gov/pubmed/20551639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000316334
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