Downregulation of Cystine Transporter x(c)(–) by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

BACKGROUND: The purpose of this study was: (1) to document the critical requirement of cystine for growth of human tumor cells in vitro, and (2) to determine the effect of the anticancer agent irinotecan on the cystine transporter x(c)(–) in head and neck FaDu xenografts. METHODS: Cell growth was me...

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Autori principali: Chintala, Sreenivasulu, Tóth, Károly, Yin, Ming-Biao, Bhattacharya, Arup, Smith, Sylvia B., Ola, M. Shamsul, Cao, Shousong, Durrani, Farukh A., Zinia, Tanjima R., Dean, Rebecca, Slocum, Harry K., Rustum, Youcef M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: S. Karger AG 2010
Soggetti:
Experimental Chemotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914432/
https://ncbi.nlm.nih.gov/pubmed/20551639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000316334
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