Hypoxia-Specific Drug Tirapazamine Does Not Abrogate Hypoxic Tumor Cells in Combination Therapy with Irinotecan and Methylselenocysteine in Well-Differentiated Human Head and Neck Squamous Cell Carcinoma A253 Xenografts

Well-differentiated hypoxic regions in head and neck squamous cell carcinoma like in A253 xenografts are avascular and, therefore, hinder drug delivery leading to drug resistance and tumor regrowth. Methylselenocysteine (MSC, 0.2 mg/mouse per day per oral for 35 days starting 7 days before the first...

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Autors principals: Bhattacharya, Arup, Tóth, Károly, Durrani, Farukh A, Cao, Shousong, Slocum, Harry K, Chintala, Sreenivasulu, Rustum, Youcef M
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2008
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481573/
https://ncbi.nlm.nih.gov/pubmed/18670644
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