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Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α

PURPOSE: Hypoxic tumor cells overexpressing hypoxia-inducible factor 1alpha (HIF-1α) are generally resistant to chemo/radiotherapy. We have reported that Se-methylselenocysteine (MSC) therapeutically enhances the efficacy and selectivity of irinotecan against human tumor xenografts. The aim of this...

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Main Authors: Chintala, Sreenivasulu, Tóth, Károly, Cao, Shousong, Durrani, Farukh A., Vaughan, Mary M., Jensen, Randy L., Rustum, Youcef M.
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2916970/
https://ncbi.nlm.nih.gov/pubmed/20066420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1238-8
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