Efficacy of increasing the therapeutic index of irinotecan, plasma and tissue selenium concentrations is methylselenocysteine dose dependent

This study was designed to understand the basis for the efficacy of methylselenocysteine (MSC) in increasing the therapeutic index of irinotecan against human tumor xenografts. Nude mice bearing human FaDu and A253 tumors were treated orally with different doses of MSC and irinotecan. Plasma, tumor...

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Hauptverfasser: Azrak, Rami G., Cao, Shousong, Pendyala, Lakshmi, Durrani, Farukh A., Fakih, Marwan, Combs, Gerald F., Prey, Joshua, Smith, Patrick F., Rustum, Youcef M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2062575/
https://ncbi.nlm.nih.gov/pubmed/17239826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2006.12.020
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