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Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity

PURPOSE: Irinotecan (CPT-11) is widely used for the treatment of patients with colorectal cancer. However, the adverse effects associated with the treatment have hindered the efficacies of irinotecan. We have shown that organic selenium compounds could significantly attenuate irinotecan-associated t...

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Autori principali: Cao, Shousong, Durrani, Farukh A., Rustum, Youcef M., Yu, Y. Eugene
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314158/
https://ncbi.nlm.nih.gov/pubmed/22237959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1820-8
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