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Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity

PURPOSE: Irinotecan (CPT-11) is widely used for the treatment of patients with colorectal cancer. However, the adverse effects associated with the treatment have hindered the efficacies of irinotecan. We have shown that organic selenium compounds could significantly attenuate irinotecan-associated t...

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Autors principals: Cao, Shousong, Durrani, Farukh A., Rustum, Youcef M., Yu, Y. Eugene
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314158/
https://ncbi.nlm.nih.gov/pubmed/22237959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1820-8
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