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Augmented therapeutic efficacy of irinotecan is associated with enhanced drug accumulation

The goal of this study is to determine whether treatment with methylselenocysteine (MSC) results in differential uptake of irinotecan and its active metabolite (SN-38) between tumors of head and neck squamous cell carcinomas and normal tissue. The in vivo synergy between MSC and irinotecan is influe...

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Detalhes bibliográficos
Main Authors: Azrak, Rami G., Cao, Shousong, Durrani, Farukh A., Toth, Karloy, Bhattacharya, Arup, Rustum, Youcef M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3183362/
https://ncbi.nlm.nih.gov/pubmed/21872389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2011.07.023
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