Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound

Tumor differentiation enhances morphologic and microvascular heterogeneity fostering hypoxia that retards intratumoral drug delivery, distribution, and compromise therapeutic efficacy. In this study, the influence of tumor biologic heterogeneity on the interaction between cytotoxic chemotherapy and...

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Detalhes bibliográficos
Main Authors: Rustum, Youcef M., Tóth, Károly, Seshadri, Mukund, Sen, Arindam, Durrani, Farukh A., Stott, Emily, Morrison, Carl D., Cao, Shousong, Bhattacharya, Arup
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860580/
https://ncbi.nlm.nih.gov/pubmed/20445750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/396286
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