Architectural Heterogeneity in Tumors Caused by Differentiation Alters Intratumoral Drug Distribution and Affects Therapeutic Synergy of Antiangiogenic Organoselenium Compound

Tumor differentiation enhances morphologic and microvascular heterogeneity fostering hypoxia that retards intratumoral drug delivery, distribution, and compromise therapeutic efficacy. In this study, the influence of tumor biologic heterogeneity on the interaction between cytotoxic chemotherapy and...

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Hauptverfasser: Rustum, Youcef M., Tóth, Károly, Seshadri, Mukund, Sen, Arindam, Durrani, Farukh A., Stott, Emily, Morrison, Carl D., Cao, Shousong, Bhattacharya, Arup
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2010
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860580/
https://ncbi.nlm.nih.gov/pubmed/20445750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2010/396286
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