Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) accounts for more than 80% of the cases of renal cell carcinoma. In ccRCC deactivation of Von-Hippel-Lindau (VHL) gene contributes to the constitutive expression of hypoxia inducible factors 1 and 2 alpha (HIF-α), transcriptional regulators of seve...

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Detalhes bibliográficos
Main Authors: Chintala, Sreenivasulu, Najrana, Tanbir, Toth, Karoly, Cao, Shousong, Durrani, Farukh A, Pili, Roberto, Rustum, Youcef M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3466155/
https://ncbi.nlm.nih.gov/pubmed/22804960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-293
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