Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition

Antzeko izenburuak

• Non-Coding Micro RNAs and Hypoxia-Inducible Factors Are Selenium Targets for Development of a Mechanism-Based Combination Strategy in Clear-Cell Renal Cell Carcinoma—Bench-to-Bedside Therapy
  nork: Rustum, Youcef M., et al.
  Argitaratua: (2018)
• Constitutive Expression of HIF-α Plays a Major Role in Generation of Clear Cell Phenotype in Human Primary and Metastatic Renal Carcinoma
  nork: Tóth, Károly, et al.
  Argitaratua: (2014)
• Hypoxia-Specific Drug Tirapazamine Does Not Abrogate Hypoxic Tumor Cells in Combination Therapy with Irinotecan and Methylselenocysteine in Well-Differentiated Human Head and Neck Squamous Cell Carcinoma A253 Xenografts
  nork: Bhattacharya, Arup, et al.
  Argitaratua: (2008)
• Se-methylselenocysteine sensitizes hypoxic tumor cells to irinotecan by targeting hypoxia-inducible factor 1α
  nork: Chintala, Sreenivasulu, et al.
  Argitaratua: (2010)
• Ugt1a is required for the protective effect of selenium against irinotecan-induced toxicity
  nork: Cao, Shousong, et al.
  Argitaratua: (2012)