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Triazine dendrimers as non-viral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity

A family of triazine dendrimers, differing in their core flexibility, generation number, and surface functionality, was prepared and evaluated for its ability to accomplish RNAi. The dendriplexes were analyzed with respect to their physicochemical and biological properties, including condensation of...

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Autors principals: Merkel, Olivia M., Mintzer, Meredith A., Librizzi, Damiano, Samsonova, Olga, Dicke, Tanja, Sproat, Brian, Garn, Holger, Barth, Peter J., Simanek, Eric E., Kissel, Thomas
Format: Artigo
Idioma:Inglês
Publicat: 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2914146/
https://ncbi.nlm.nih.gov/pubmed/20524664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp100101s
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