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Computational Insights into the Interactions between DNA and siRNA with “Rigid” and “Flexible” Triazine Dendrimers

In this study, simulation challenges intuitive models of “flexible” and “rigid” generation two triazine dendrimers as it pertains to solution conformation and conformation on binding DNA or siRNA sequences. These results derive from structural and energetic analyses of the binding events. Simulation...

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Main Authors: Pavan, Giovanni M., Mintzer, Meredith A., Simanek, Eric E., Merkel, Olivia M., Kissel, Thomas, Danani, Andrea
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3841066/
https://ncbi.nlm.nih.gov/pubmed/20131771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm901298t
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