Crystal structure of the APOBEC3G catalytic domain reveals potential oligomerization interfaces

APOBEC3G is a DNA cytidine deaminase that has anti-viral activity against HIV-1 and other pathogenic viruses. In this study the crystal structure of the catalytically active C-terminal domain was determined to 2.25 Å. This structure corroborates features previously observed in NMR studies, a bulge i...

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Hauptverfasser: Shandilya, Shivender M. D., Nalam, Madhavi N. L., Nalivaika, Ellen A., Gross, Phillip J., Valesano, John C., Shindo, Keisuke, Li, Ming, Munson, Mary, Harjes, Elena, Kouno, Takahide, Matsuo, Hiroshi, Harris, Reuben S., Somasundaran, Mohan, Schiffer, Celia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913127/
https://ncbi.nlm.nih.gov/pubmed/20152150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2009.10.016
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