Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

Personalized cancer medicine is based on the concept that targeted therapies are effective on subsets of patients whose tumors carry specific molecular alterations. Several mammalian target of rapamycin (mTOR) inhibitors are in preclinical or clinical trials for cancers, but the molecular basis of s...

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Главные авторы: Di Nicolantonio, Federica, Arena, Sabrina, Tabernero, Josep, Grosso, Stefano, Molinari, Francesca, Macarulla, Teresa, Russo, Mariangela, Cancelliere, Carlotta, Zecchin, Davide, Mazzucchelli, Luca, Sasazuki, Takehiko, Shirasawa, Senji, Geuna, Massimo, Frattini, Milo, Baselga, José, Gallicchio, Margherita, Biffo, Stefano, Bardelli, Alberto
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2010
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912177/
https://ncbi.nlm.nih.gov/pubmed/20664172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37539
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