BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative study

BACKGROUND: Colorectal cancer is a common disease that involves genetic alterations, such as inactivation of tumour suppressor genes and activation of oncogenes. Among them are RAS and BRAF mutations, which rarely coexist in the same tumour. Individual members of the Rho (Ras homology) GTPases contr...

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Detalhes bibliográficos
Main Authors: Makrodouli, Eleni, Oikonomou, Eftychia, Koc, Michal, Andera, Ladislav, Sasazuki, Takehiko, Shirasawa, Senji, Pintzas, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3189908/
https://ncbi.nlm.nih.gov/pubmed/21943101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-118
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