Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus

Personalized cancer medicine is based on the concept that targeted therapies are effective on subsets of patients whose tumors carry specific molecular alterations. Several mammalian target of rapamycin (mTOR) inhibitors are in preclinical or clinical trials for cancers, but the molecular basis of s...

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Bibliographic Details
Main Authors: Di Nicolantonio, Federica, Arena, Sabrina, Tabernero, Josep, Grosso, Stefano, Molinari, Francesca, Macarulla, Teresa, Russo, Mariangela, Cancelliere, Carlotta, Zecchin, Davide, Mazzucchelli, Luca, Sasazuki, Takehiko, Shirasawa, Senji, Geuna, Massimo, Frattini, Milo, Baselga, José, Gallicchio, Margherita, Biffo, Stefano, Bardelli, Alberto
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2010
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912177/
https://ncbi.nlm.nih.gov/pubmed/20664172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37539
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