α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors

Autotaxin (ATX) is an attractive pharmacological target due to its lysophospholipase D activity which leads to the production of lysophosphatidic acid (LPA). Blockage of ATX produced LPA by small molecules could be a potential anticancer chemotherapy. In our previous study, we have identified the tw...

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Main Authors: Cui, Peng, McCalmont, William F., Tomsig, Jose L., Lynch, Kevin R., Macdonald, Timothy L.
Formato: Artigo
Idioma:Inglês
Publicado: 2007
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2907913/
https://ncbi.nlm.nih.gov/pubmed/18082408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2007.11.078
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