Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein found in islet cells of patients with type II diabetes. Because hIAPP is highly toxic to beta-cells under certain conditions, it has been proposed that hIAPP is linked to the loss of beta-cells and insulin secretion in type II...

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Main Authors: Brender, Jeffrey R., Hartman, Kevin, Nanga, Ravi Prakash Reddy, Popovych, Natalya, de la Salud Bea, Roberto, Vivekanandan, Subramanian, Marsh, E. Neil G., Ramamoorthy, Ayyalusamy
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904811/
https://ncbi.nlm.nih.gov/pubmed/20536124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja1007867
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