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Structure and Membrane Orientation of IAPP in its Natively Amidated Form at Physiological pH in a Membrane Environment
Human islet amyloid polypeptide is a hormone coexpressed with insulin by pancreatic beta-cells. For reasons not clearly understood, hIAPP aggregates in type II diabetics to form oligomers that interfere with beta-cell function, eventually leading to the loss of insulin production. The cellular membr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3156962/ https://ncbi.nlm.nih.gov/pubmed/21723249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2011.06.012 |
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