A Two Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc

Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein cosecreted with insulin in response to glucose levels. The formation of hIAPP amyloid plaques near islet cells has been linked to the death of insulin-secreting beta-cells in humans and the progression of type II diabetes. Sin...

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Main Authors: Salamekh, Samer, Brender, Jeffrey R., Hyung, Suk-Joon, Nanga, Ravi Prakash Reddy, Vivekanandan, Subramanian, Ruotolo, Brandon T., Ramamoorthy, Ayyalusamy
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3115507/
https://ncbi.nlm.nih.gov/pubmed/21616080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.05.015
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