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A Two Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc
Human Islet Amyloid Polypeptide (hIAPP) is a highly amyloidogenic protein cosecreted with insulin in response to glucose levels. The formation of hIAPP amyloid plaques near islet cells has been linked to the death of insulin-secreting beta-cells in humans and the progression of type II diabetes. Sin...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3115507/ https://ncbi.nlm.nih.gov/pubmed/21616080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.05.015 |
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