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Structures of Rat and Human Islet Amyloid Polypeptide IAPP(1–19) in Micelles by NMR Spectroscopy

Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert fibrillar form of IAPP has been investigated, the structural details of the highly toxic prefibrillar membrane-bound s...

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Detalhes bibliográficos
Main Authors: Nanga, Ravi Prakash Reddy, Brender, Jeffrey R., Xu, Jiadi, Veglia, Gianluigi, Ramamoorthy, Ayyalusamy
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2953382/
https://ncbi.nlm.nih.gov/pubmed/18989932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8014357
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