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Structures of Rat and Human Islet Amyloid Polypeptide IAPP(1–19) in Micelles by NMR Spectroscopy
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert fibrillar form of IAPP has been investigated, the structural details of the highly toxic prefibrillar membrane-bound s...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2008
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2953382/ https://ncbi.nlm.nih.gov/pubmed/18989932 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8014357 |
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