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Alternative Pathways of Human Islet Amyloid Polypeptide Aggregation Distinguished by (19)F NMR-Detected Kinetics of Monomer Consumption

Amyloid formation, a complex process involving many intermediate states, is proposed to be the driving force for amyloid-related toxicity in common degenerative diseases. Unfortunately, the details of this process have been obscured by the limitations in the methods that can follow this reaction in...

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Detalhes bibliográficos
Main Authors: Suzuki, Yuta, Brender, Jeffrey R., Hartman, Kevin, Ramamoorthy, Ayyalusamy, G. Marsh, E. Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3543753/
https://ncbi.nlm.nih.gov/pubmed/22998665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3012548
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