Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide (IAPP or amylin). IAPP is stored before secretion at millimolar concentrations within secretory granules inside the β-cells. Of interest, at thes...

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Detalhes bibliográficos
Main Authors: Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2011
Assuntos:
Protein
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030259/
https://ncbi.nlm.nih.gov/pubmed/21281583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.070
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