Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide (IAPP or amylin). IAPP is stored before secretion at millimolar concentrations within secretory granules inside the β-cells. Of interest, at thes...

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Dettagli Bibliografici
Autori principali: Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2011
Soggetti:
Protein
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030259/
https://ncbi.nlm.nih.gov/pubmed/21281583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.070
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