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Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide (IAPP or amylin). IAPP is stored before secretion at millimolar concentrations within secretory granules inside the β-cells. Of interest, at thes...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2011
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030259/
https://ncbi.nlm.nih.gov/pubmed/21281583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.070
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