Biphasic Effects of Insulin on Islet Amyloid Polypeptide Membrane Disruption

Type II diabetes, in its late stages, is often associated with the formation of extracellular islet amyloid deposits composed of islet amyloid polypeptide (IAPP or amylin). IAPP is stored before secretion at millimolar concentrations within secretory granules inside the β-cells. Of interest, at thes...

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Dades bibliogràfiques
Autors principals: Brender, Jeffrey R., Lee, Edgar L., Hartman, Kevin, Wong, Pamela T., Ramamoorthy, Ayyalusamy, Steel, Duncan G., Gafni, Ari
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2011
Matèries:
Protein
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3030259/
https://ncbi.nlm.nih.gov/pubmed/21281583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.09.070
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