Membrane Fragmentation by an Amyloidogenic Fragment of Human Islet Amyloid Polypeptide Detected by Solid-State NMR Spectroscopy of Membrane Nanotubes

A key factor in the development of Type II diabetes is the loss of insulin producing pancreatic β-cells. The amyloidogenic human Islet Amyloid Polypeptide (hIAPP also known as human amylin) is believed to play a crucial role in this biological process. Previous studies have shown that hIAPP forms sm...

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Main Authors: Brender, Jeffrey R., Dürr, Ulrich H.N., Heyl, Deborah, Budarapu, Mahender B., Ramamoorthy, Ayyalusamy
格式: Artigo
語言:Inglês
出版: 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042489/
https://ncbi.nlm.nih.gov/pubmed/17662957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2007.07.001
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