Membrane Disordering is not Sufficient for Membrane Permeabilization by Islet Amyloidogenic Polypeptide: Studies of IAPP(20-29) Fragments

A key factor in the development of type II diabetes is the loss of insulin-producing beta-cells. Human islet amyloid polypeptide protein (human-IAPP) is believed to play a crucial role in this process by forming small aggregates that exhibit toxicity by disrupting the cell membrane. The actual mecha...

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Main Authors: Brender, Jeffrey R., Heyl, Deborah L., Samisetti, Shyamprasad, Kotler, Samuel A., Osborne, Joshua M., Pesaru, Ranadheer R., Ramamoorthy, Ayyalusamy
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3663912/
https://ncbi.nlm.nih.gov/pubmed/23493863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cp44696d
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