Selection for Non-Amyloidogenic Mutants of Islet Amyloid Polypeptide (IAPP) Identifies an Extended Region for Amyloidogenicity

The aggregation of the 37-residue polypeptide IAPP, as either insoluble amyloid or as small oligomers, appears to play a direct role in the death of pancreatic β-islet cells in type II diabetes. While IAPP has been known to be the primary component of type II diabetes amyloid, the molecular interact...

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Main Authors: Fox, Ayano, Snollaerts, Thibaut, Casanova, Camille Errecart, Calciano, Anastasia, Nogaj, Luiza A., Moffet, David A.
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2963167/
https://ncbi.nlm.nih.gov/pubmed/20698575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100337p
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