Gain of Function in FHM-1 Ca(v)2.1 Knock-In Mice Is Related to the Shape of the Action Potential

Familial hemiplegic migraine type-1 FHM-1 is caused by missense mutations in the CACNA1A gene that encodes the α(1A) pore-forming subunit of Ca(V)2.1 Ca(2+) channels. We used knock-in (KI) transgenic mice harboring the pathogenic FHM-1 mutation R192Q to study neurotransmission at the calyx of Held s...

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Auteurs principaux: Inchauspe, Carlota González, Urbano, Francisco J., Di Guilmi, Mariano N., Forsythe, Ian D., Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Uchitel, Osvaldo D.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2010
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904224/
https://ncbi.nlm.nih.gov/pubmed/20484531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00034.2010
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