Synaptic Gain-of-Function Effects of Mutant Ca(v)2.1 Channels in a Mouse Model of Familial Hemiplegic Migraine Are Due to Increased Basal [Ca(2+)](i)

Specific missense mutations in the CACNA1A gene, which encodes a subunit of voltage-gated Ca(V)2.1 channels, are associated with familial hemiplegic migraine type 1 (FHM1), a rare monogenic subtype of common migraine with aura. We used transgenic knock-in (KI) mice harboring the human pathogenic FHM...

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Auteurs principaux: Di Guilmi, Mariano N., Wang, Tiantian, Inchauspe, Carlota Gonzalez, Forsythe, Ian D., Ferrari, Michel D., van den Maagdenberg, Arn M.J.M., Borst, J. Gerard G., Uchitel, Osvaldo D.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2014
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4028489/
https://ncbi.nlm.nih.gov/pubmed/24849341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2526-13.2014
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