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Pregabalin Modulation of Neurotransmitter Release Is Mediated by Change in Intrinsic Activation/Inactivation Properties of Ca(v)2.1 Calcium Channels

In this work, we studied the effects of the anticonvulsant and analgesic drug pregabalin (PGB) on excitatory postsynaptic currents (EPSCs) at principal neurons of the mouse medial nucleus of the trapezoid body and on presynaptic calcium currents at the calyx of Held. We found that the acute applicat...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Di Guilmi, Mariano N., Urbano, Francisco J., Inchauspe, Carlota Gonzalez, Uchitel, Osvaldo D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061532/
https://ncbi.nlm.nih.gov/pubmed/21177783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172171
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