Pregabalin Modulation of Neurotransmitter Release Is Mediated by Change in Intrinsic Activation/Inactivation Properties of Ca(v)2.1 Calcium Channels

In this work, we studied the effects of the anticonvulsant and analgesic drug pregabalin (PGB) on excitatory postsynaptic currents (EPSCs) at principal neurons of the mouse medial nucleus of the trapezoid body and on presynaptic calcium currents at the calyx of Held. We found that the acute applicat...

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Bibliographic Details
Main Authors: Di Guilmi, Mariano N., Urbano, Francisco J., Inchauspe, Carlota Gonzalez, Uchitel, Osvaldo D.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Neuropharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3061532/
https://ncbi.nlm.nih.gov/pubmed/21177783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.172171
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