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Abnormal cortical synaptic transmission in Ca(V)2.1 knockin mice with the S218L missense mutation which causes a severe familial hemiplegic migraine syndrome in humans
Familial hemiplegic migraine type 1 (FHM1) is caused by gain-of-function mutations in Ca(V)2.1 (P/Q-type) Ca(2+) channels. Knockin (KI) mice carrying the FHM1 R192Q missense mutation show enhanced cortical excitatory synaptic transmission at pyramidal cell synapses but unaltered cortical inhibitory...
Gorde:
| Argitaratua izan da: | Front Cell Neurosci |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Frontiers Media S.A.
2015
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4330891/ https://ncbi.nlm.nih.gov/pubmed/25741235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2015.00008 |
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