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Gain of Function in FHM-1 Ca(v)2.1 Knock-In Mice Is Related to the Shape of the Action Potential
Familial hemiplegic migraine type-1 FHM-1 is caused by missense mutations in the CACNA1A gene that encodes the α(1A) pore-forming subunit of Ca(V)2.1 Ca(2+) channels. We used knock-in (KI) transgenic mice harboring the pathogenic FHM-1 mutation R192Q to study neurotransmission at the calyx of Held s...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904224/ https://ncbi.nlm.nih.gov/pubmed/20484531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00034.2010 |
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