The Structure of Neisseria meningitidis Lipid A Determines Outcome in Experimental Meningococcal Disease

Lipopolysaccharide (LPS), a major component of the meningococcal outer membrane, is sensed by the host through activation of Toll-like receptor 4 (TLR4). Recently, we demonstrated that a surprisingly large fraction of Neisseria meningitidis disease isolates are lipid A mutants, due to inactivating m...

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Autori principali: Fransen, Floris, Hamstra, Hendrik Jan, Boog, Claire J., van Putten, Jos P., van den Dobbelsteen, Germie P. J. M., van der Ley, Peter
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
Soggetti:
Bacterial Infections
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897371/
https://ncbi.nlm.nih.gov/pubmed/20439476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01311-09
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