Differential Activation of Human and Mouse Toll-Like Receptor 4 by the Adjuvant Candidate LpxL1 of Neisseria meningitidis

Neisseria meningitidis LpxL1 lipopolysaccharide (LPS) bearing penta-acylated lipid A is considered a promising adjuvant candidate for inclusion in future N. meningitidis vaccines, as it elicits a markedly reduced endotoxic response in human macrophages relative to that in wild-type (hexa-acylated) L...

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Main Authors: Steeghs, Liana, Keestra, A. Marijke, van Mourik, Andries, Uronen-Hansson, Heli, van der Ley, Peter, Callard, Robin, Klein, Nigel, van Putten, Jos P. M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Bacterial Infections
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493235/
https://ncbi.nlm.nih.gov/pubmed/18490457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00005-08
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