Development of Hexadecyloxypropyl Tenofovir (CMX157) for Treatment of Infection Caused by Wild-Type and Nucleoside/Nucleotide-Resistant HIV

CMX157 is a lipid (1-0-hexadecyloxypropyl) conjugate of the acyclic nucleotide analog tenofovir (TFV) with activity against both wild-type and antiretroviral drug-resistant HIV strains, including multidrug nucleoside/nucleotide analog-resistant viruses. CMX157 was consistently >300-fold more acti...

Full description

Saved in:
Bibliographic Details
Main Authors: Lanier, E. Randall, Ptak, Roger G., Lampert, Bernhard M., Keilholz, Laurie, Hartman, Tracy, Buckheit, Robert W., Mankowski, Marie K., Osterling, Mark C., Almond, Merrick R., Painter, George R.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897300/
https://ncbi.nlm.nih.gov/pubmed/20439609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00068-10
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items